产品说明
一般描述
Phosphohistone H3 (PHH3) is a core histone protein, which together with other histones, forms the major protein constituents of the chromatin in eukaryotic cells. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis. Immunohistochemical studies showed anti-PHH3 specifically detected the core protein histone H3 only when phosphorylated at serine 10 or serine 28. Studies have also revealed no phosphorylation on the histone H3 during apoptosis. Therefore, PHH3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, gyn., soft tissue, and GIST.
质量
 IVD |  IVD |  IVD |  RUO |
联系
Phosphohistone H3 (PHH3) Positive Control Slides, Product No. 369S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 500 100 |
| 偶联物 | unconjugated |
| 抗体形式 | Ig fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 描述 | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 包装 | vial of 0.1 mL concentrate (369A-14) vial of 0.5 mL concentrate (369A-15) bottle of 1.0 mL predilute (369A-17) vial of 1.0 mL concentrate (369A-16) bottle of 7.0 mL predilute (369A-18) |
| manufacturer/tradename | Cell Marque™ |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 |
| 控制 | tonsil |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| 可视化 | nuclear |
