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c-Myc (EP121) Rabbit Monoclonal Primary Antibody

品牌
Sigma-Aldrich
货号
395R-1
规格纯度
价格
2021.77 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Burkitt lymphoma (BL) can be morphologically indistinguishable from diffuse large B-cell lymphoma (DLBCL).The 2008 WHO classification includes a subcategory of aggressive lymphomas characterized by features intermediate between DLBCL and BL in order to accommodate cases in the gray zone between BL and DLBCL. Rearrangement of the MYC gene is found in 3% to 16% of DLBCLs and in nearly 100% of BL.Identifying MYC status is important in establishing final diagnosis of DLBCL, BL, or B-cell lymphoma, with features intermediate between DLBCL and BL as well as in differential diagnoses of the lymphomas. Results from one study have shown immunohistochemical (IHC) expression of MYC protein by c-Myc antibody in 219 cases of aggressive DLBCL and 7 cases of BL.Nuclear MYC protein expression detected by IHC has shown high sensitivity and specificity in identifying a MYC rearrangement in aggressive DLBCL and BL when at least 70% of lymphoma cells show nuclear positivity.
The IHC c-Myc assay, combined with other antibodies, such as those against CD10, BCL2, and Ki67, is very useful in identifying cases for which MYC FISH analysis is warranted or can be omitted.There are reports that nuclear overexpression of MYC protein occur frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease. However, MYC protein overexpression has yet to be correlated with gain of MYC gene (8q24), suggesting alternative mechanisms for MYC protein overexpression.

质量


IVD

IVD

IVD

RUO

联系

c-Myc Positive Control Slides, Product No. 395S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平500
100
偶联物unconjugated
抗体形式culture supernatant
antibody product typeprimary antibodies
克隆EP121, monoclonal
描述For In Vitro Diagnostic Use in Select Regions (See Chart)
形式buffered aqueous solution
species reactivityhuman
包装vial of 0.1 mL concentrate (395R-14)
vial of 0.5 mL concentrate (395R-15)
bottle of 1.0 mL predilute (395R-17)
vial of 1.0 mL concentrate (395R-16)
bottle of 7.0 mL predilute (395R-18)
manufacturer/tradenameCell Marque
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型IgG
控制Burkitt lymphoma, prostate carcinoma
运输wet ice
储存温度2-8℃
可视化nuclear

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