The claudins are a family of over twenty proteins which are components of tight junctions. Tight junctions are specialized regions of cell-to-cell contact made up of a network of strands to act as a molecular ‘gasket′ for preventing the leakage of ions, water, etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. The claudins constitute a variable component, with specific claudins being associated with specific tissues. The immunoreactivity for anti-claudin 1 is membranous and is found in nearly all carcinomas. The staining is much stronger in the carcinoma cells than in normal tissues. Anti-claudin 1 in a panel of immunostains that includes antibodies against EMA (positive), S-100 (negative), and GLUT1 can be utilized as a robust marker in the diagnosis of perineurioma and neurofibroma. Some studies have shown anti-claudin 1 to be a specific marker for meningiomas. Therefore, anti-claudin 1 with anti-EMA, anti-S-100 protein, anti-CD34, and anti-glial fibrillary acidic protein (GFAP) may be helpful in the differentiation of meningiomas from histologic mimics.
Claudin 1 Positive Control Slides, Product No. 359S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
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|抗体形式||Ig fraction of antiserum|
|antibody product type||primary antibodies|
|描述||For In Vitro Diagnostic Use in Select Regions (See Chart)|
|形式||buffered aqueous solution|
|包装||vial of 0.1 mL concentrate (359A-14)|
vial of 0.5 mL concentrate (359A-15)
bottle of 1.0 mL predilute (359A-17)
vial of 1.0 mL concentrate (359A-16)
bottle of 7.0 mL predilute (359A-18)
|technique(s)||immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100|
|控制||colon carcinoma, neurofibroma|
|储存分类代码||12 - Non Combustible Liquids|