| 英文名称: | | 9,1-epoxy-1h-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazoci ne-1 | | 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-0- carboxylic aci methyl | | (9-alpha,10-beta,12-alpha)-este | | antibiotic k 252a | | antibiotic sf 2370 | | k252a | | sf 2370 | | protein kinase inhibitor from norcardiopsis sp. |
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| 用途: | K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively |
