CAS NO:595-33-5; 甲地孕酮醋酸酯

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CAS:

595-33-5

分子式:

C24H32O4

分子量:

384.52

熔点:

214°C

闪点:

218.5ºC

沸点:

507.1ºC

密度:

1.15g/cm3

中文名称:

甲地孕酮醋酸酯

17α-乙酰氧基-6-甲基孕甾-4,6-二烯-3,20-二酮

6-甲基孕甾-4,6-二烯-17α-醇-3,20-二酮-17-醋酸酯

17α-羟基-6-甲基孕甾-4,6-二烯-3,20-二酮17-醋酸酯

英文名称:

6-diene-3,20-dione, 17-hydroxy-6-methyl-pregna- acetate

17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione

17-acetoxy-6-methylpregna-4,6-diene-3,20-dione

17-alpha-acetoxy-6-dehydro-6-methylprogesterone

17-alpha-acetoxy-6-methyl-4,6-pregnadiene-3,20-dione

17-alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione

17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate

6-dehydro-6-methyl-17-alpha-acetoxyprogesterone

6-methyl-17-alpha-acetoxypregna-4,6-diene-3,20-dione

6-methyl-17-alpha-hydroxy-delta(sup 6)-progesterone acetate

6-methyl-6-dehydro-17-alpha-acetoxyprogesterone

6-methyl-6-dehydro-17-alpha-acetylprogesterone

6-methyl-delta(sup 4,6)-pregnadien-17-alpha-ol-3,20-dione acetate

6-methyl-delta(sup 6)-dehydro-17-alpha-acetoxyprogesterone

bdh 1298

megace

megeron

megestryl acetate

niagestin

nsc-71423

ovaban

sc10363

17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate

17α-Acetoxy-6-methyl-4,6-pregnadiene-3,20-dione

17-Acetyloxy-6-methylpregna-4,6-diene-3,20-dione

Megestrol-17-acetate

性质描述:

白色或微黄色结晶性粉末（甲醇），无嗅无味。熔点214-216℃ 。溶于丙酮，微溶于乙醇、乙醚，不溶于水。

生产方法:

可用16,17α-环氧黄体酮经溴化氢开环及镍催化还原脱溴，生成17α-羟基黄体酮，再经乙酰化及酸水解生成17α-乙酰氧基黄体酮，然后以原甲酸三乙酯醚化及Vilsmeier反应得3-乙氧基-6-甲酰基-17α-乙酰氧基孕甾-2,5-二烯-20-酮，最后以硼氢化钾还原，酸水解、脱水并转位制得该品。

用途:

安宫黄体酮（甲孕酮）的中间体。

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