CAS NO:4342-03-4; 达卡巴嗪

CAS:

4342-03-4

分子式:

C6H10N6O

分子量:

182.18

中文名称:

达卡巴嗪

氮烯咪胺

三氮烯咪唑胺

三嗪咪唑胺

甲嗪咪唑胺

5-(3,3-二甲基-1-三氮烯)咪唑-4-羧酰胺

抗黑瘤

氮烯唑胺

英文名称:

5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamid

(dimethyltriazeno)imidazolecarboxamide

5-(3,3-dimethyl-1-triazenyl)-1 h-imidazole-4-carboxamid

5-(3,3-dimethyl-1-triazenyl)-1h-imidazole-4-carboxamid

4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide

4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide

4-(dimethyltriazeno)imidazole-5-carboxamide

5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide

5-(3,3-dimethyltriazeno)imidazole-4-carboxamide

5-(dimethyltriazeno)imidazole-4-carboxamide

biocarbazine r

dacarbazine

deticene

dic

dtic

dtic-aome

dtic-dome

5-(3,3-dimethyl-1-triazeno1-imidazole-4-carboxamid

nci-c04717

nsc-45388

5-(3,3-Dimethyl-1-triazenyl)-1H-imidazde-4-carboxamide

性质描述:

微黄色结晶或粉末。熔点205℃，也有报道250-255℃（分解）。易溶于酸，微溶于甲醇，乙醇，不溶于水。遇热分解，对酸和光不稳定。

生产方法:

以氰乙酸乙酯为原料，经加成、胺化、重氮化、偶合、还原、甲酰化、环合、中和、重氮化、缩合，经过中间体β-亚胺基-β-乙氧基丙酸乙酯盐酸盐，α-脒基乙酰胺盐酸盐，α-脒基-α-苯偶氮基乙酰胺盐酸盐，5-氨基咪唑-4-羧酰胺盐酸盐而得。

用途:

抗肿瘤药。临床上用于恶性黑色素瘤，约20-30%有效，与长春醛碱和卡氮芥合并应用，可提高疗效。此外对肺鳞癌、肉瘤、平滑肌肉瘤、纤维肉瘤亦有一定疗效。对消化道癌的疗效不佳。

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