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| CAS: | 387867-13-2 |
| 分子式: | C31H42N6O4 |
| 分子量: | 562.72 |
| 熔点: | 172-183 °C |
| 中文名称: | | 坦度替尼 | | 4-[6-甲氧基-7-(3-哌啶-1-基丙氧基)喹唑啉-4-基]-n-(4-异丙基氧苯基)哌嗪-1-甲酰胺 |
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| 英文名称: | | tandutinib (mln518) | | mln518 | | ct53518 | | mln 518 | | ct 53518 | | mln-518 | | ct-53518 | | 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-n-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide | | (4-(6-methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-n-(4-(methylethoxy)phenyl)carboxamide |
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| 用途: | Tandutinib (MLN518)是一种有效的FLT3拮抗剂，IC50为0.22 μM，同时也抑制PDGFR和c-Kit，对FLT3作用效果比CSF-1R强15到20倍，比FGFR， EGFR和KDR等强100倍以上 |
