CAS NO:371980-98-2; sb-612111 hydrochloride

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CAS:

371980-98-2

分子式:

C₂₄H₂₉Cl₂NO · HCl

分子量:

454.86

英文名称:

sb-612111 hydrochloride

(5S,7S)-7-[[4-(2,6-dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5h-benzocyclohepten-5-ol hydrochloride

用途:

SB-612111 is a potent antagonist of the nociceptin receptor ORL-1. SB-612111 binds to ORL-1 with high affinity (Ki = 0.33 nM) but has very low affinity for classic opioid receptors. The compound SB-612111 antagonizes the anti-morphine effects of nociceptin and blocks nociceptin-induced thermal hyperalgesia.