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| CAS: | 367514-87-2 |
| 分子式: | C28H36N4O2S |
| 分子量: | 492.68 |
| 中文名称: | | 鲁拉西酮 | | (3ar,4S,7R,7as)-2-[[(1R,2R)-2-[[4-(苯并[d]异噻唑-3-基)吡嗪-1-基]甲基]环己基]甲基]六氢-1h-4,7-甲基异吲哚-1,3(2h)-二酮 |
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| 英文名称: | | lurasidone | | (3ar,4S,7R,7as)-2-[[(1R,2R)-2-[[4-(benzo[d]isothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]hexahydro-1h-4,7-methanoisoindole-1,3(2h)-dione |
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| 用途: | Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors. |
