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| 首页\化工字典\CAS NO:2408648-20-2 |
| CAS: | 2408648-20-2 | |
| 分子式: | C18H19N5O3 | |
| 分子量: | 353.370 | |
| 中文名称: |
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| 用途: | BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity[1]. |