CAS NO:1616287-82-1; pf-06726304 acetate

CAS:

1616287-82-1

分子式:

C₂₂H₂₁Cl₂N₃O₃

分子量:

446.33

英文名称:

pf-06726304 acetate

5,8-dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2h)-isoquinolinone acetate

用途:

PF-06726304是选择性EZH2抑制剂，对WT EZH2和EZH2(Y641N)的Ki值分别为0.7 nM和3 nM。抑制H3K27me3的IC50为15 nM。