CAS NO:1610964-64-1; 5-fluoro-2-(6-fluoro-2-methyl-1h-benzo[d]imidazol-1-yl)-n4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine

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CAS:

1610964-64-1

分子式:

C₁₉H₁₃F₅N₆

分子量:

420.330

英文名称:

5-fluoro-2-(6-fluoro-2-methyl-1h-benzo[d]imidazol-1-yl)-n4-(4-(trifluoromethyl)phenyl)pyrimidine-4,6-diamine

用途:

PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells.

推荐供应商

货号	品牌	产品名称	规格	包装、参考价格	详情
P910243	MACKLIN	PTC596	98%	910元/5mg; 1420元/10mg;	展开
储存：-20°C，密闭，干燥状态：固体
P798112	MACKLIN	PTC596	10mM in DMSO	684元/1ml;	展开
储存：-20°C