| |
| 首页\化工字典\CAS NO:160807-49-8 |
| CAS: | 160807-49-8 | ||||
| 分子式: | C16H11N3O2 | ||||
| 分子量: | 277.28 | ||||
| 中文名称: |
| ||||
| 用途: | Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC50=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 μM). Indirubin-3'-monoxime is an inhibitor of Cdk2, cyclin A, cyclin B, cyclin E and p35. |