CAS NO:1373615-35-0; 1-[4-(5′-chloro-3,5-dimethyl-2,4′-bipyridin-2′-yl)piperazin-1-yl] -3- (methylsulfonyl)propan-1-one hydrochloride

CAS:

1373615-35-0

分子式:

C₂₀H₂₅ClN₄O₃S

分子量:

436.96

中文名称:

1-[4-(5′-chloro-3,5-dimethyl-2,4′-bipyridin-2′-yl)piperazin-1-yl] -3- (methylsulfonyl)propan-1-one hydrochloride

英文名称:

pf-5274857 hydrochloride

用途:

PF-5274857是一种有效的，选择性Smoothened(Smo)拮抗剂，抑制Hedgehog (Hh)信号通路，IC50和Ki分别为5.8 nM和4.6 nM，可以穿透血脑屏障。