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| CAS: | 1369773-39-6 |
| 分子式: | C48H56CaN2O10 |
| 分子量: | 861.04 |
| 中文名称: | | 沙卡布曲 钙盐 | | ahu377 钙盐 | | ahu-377 钙盐 | | 4-{[(2S,4R)-1-(4-联苯基)-5-乙氧基-4-甲基-5-氧代-2-戊烷基]氨基}-4-氧代丁酸；(2R,4S)-5-(联苯-4-基)-4-[(3-羧基丙酰基)氨基]-2-甲基戊酸乙酯 | | (2R,4S)-4-[(3-羧基-1-丙酰基)氨基]-4-[(对-联苯基)甲基]-2-甲基丁酸乙酯 | | 4-[[(2S,4R)-5-乙氧基-4-甲基-5-氧代-1-(4-联苯基)戊烷-2-基]氨基]-4-氧代丁酸 钙盐 |
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| 英文名称: | | sacubitril calcium salt | | (2R,4S)-4-[(3-carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester | | ahu-377 calcium salt | | 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid calcium salt | | ahu377 calcium salt | | 4-{[(2S,4R)-1-(4-biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid; (2R,4S)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester |
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| 用途: | Sacubitril (AHU377)是膜金属内肽酶neprilysin的前药抑制剂。Sacubitril与血管紧张素受体阻滞剂缬沙坦一起构成了一半的心力衰竭联合药物LCZ696。Sacubitril (AHU377)被酯酶转化为活性抑制剂LBQ657，它可以防止心房和脑利钠肽(两种降压肽)的新蛋白酶s降解。AHU377缬沙坦联合药物LCZ696与标准血管紧张素转换酶抑制剂依那普利相比，心血管死亡风险降低了20%，住院风险降低了21%。 |
