| 英文名称: | | cp-94,253 dihydrochloride | | cp-94253 hydrochloride | | 3- (1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3, 2-b] pyridine hydrochloride | | 1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5h-pyrrol[3,2-b]pyridin-5-one dihydrochloride | | 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-pyrrolo[3,2-b]pyridine hydrochloride |
|
| 用途: | CP-94,253 is a potent and selective serotonin 5-HT1B receptor agonist with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors. Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively. CP-94,253 was found to be anxiolytic in animal models; dose-dependently enhanced reinforcing effects of cocaine (self-administration);and reduced food intake. |
