CAS NO:1301214-47-0; 1,4-dihydro-1′-[(2-methyl-1h-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5h-indazole-5,4′-piperidin]-7(6h)-one

CAS:

1301214-47-0

分子式:

C₂₃H₂₇N₅O₂

分子量:

405.49

中文名称:

1,4-dihydro-1′-[(2-methyl-1h-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5h-indazole-5,4′-piperidin]-7(6h)-one

1-异丙基-1-(2-甲基-1h-苯并[d]咪唑-6-羰基)-1,4-二氢螺并[吲唑-5,4-哌啶] -7(6h)-酮

1,4-二氢-1′-[(2-甲基-1h-苯并咪唑-6-羰基)-1,4-二氢螺并[吲唑-5,4′-哌啶]-7(6h)-酮

英文名称:

pf-05175157

1-isopropyl-1-(2-methyl-1h-benzo[d]imidazole-6-carbonyl)-1,4-dihydrospiro[indazole-5,4-piperidin]-7(6h)-one

用途:

PF-05175157 是一种广谱乙酰辅酶 A 羧化酶 (ACC) 抑制剂，对 ACC1 (human)，ACC2 (human)， ACC1 (rat) 和 ACC2 (rat) 的 IC50 值分别为 27.0, 33.0, 23.5 和 50.4 nM。