CAS NO:1146699-66-2; avagacestat

CAS:

1146699-66-2

分子式:

C₂₀H₁₇ClF₄N₄O₄S

分子量:

520.88

英文名称:

avagacestat

(2R)-2-[n-[(4-chlorophenyl)sulfonyl]-n-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

(R)-2-(4-chloro-n-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)phenylsulfonamido)-5,5,5-trifluoropentanamide

bms-708163

用途:

Avagacestat (BMS-708163)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM，比作用于Notch选择性高193倍。Phase 2。