产品说明
一般描述
The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3. It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase.
应用
Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA).
生化/生理作用
Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.
外形
Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.
制备说明
Expressed as a soluble protein and purified under non-denaturing conditions.
基本信息
| MDL编号 | MFCD03454663 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in E. coli (N-terminal histidine tagged) |
| 测定 | >90% (SDS-PAGE) |
| 形式 | buffered aqueous solution |
| 分子量 | ~100 kDa by SDS-PAGE |
| UniProt登记号 | P05067 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... APP(351) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
