产品说明
应用
Human ZAP-70 Tyrosine Kinase was used for mapping the phosphorylation sites on LAT (linker for activation of T cells) for investigating the mechanism of activation of signalling proteins in T cells.
生化/生理作用
ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration.
ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues.
单位定义
One unit will phosphorylate 1 nmol polyglutamic acid:tyrosine per min at 37 ℃ at pH 7.0.
外形
Solution in 25 mM HEPES, pH 7.5, containing 150 mM NaCl, 0.5 mM DTT, and 50% glycerol.
基本信息
| MDL编号 | MFCD03459122 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in baculovirus infected insect cells (Histidine tagged) |
| 测定 | ≥90% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | ≥150 U/mg |
| 分子量 | 70 kDa |
| UniProt登记号 | P43403 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... ZAP70(7535) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
