Erastin2

产品介绍：

产品说明

生化/生理作用

Erastin2 is an Erastin analog with greatly improved system xc- (SLC7A11/xCT + SLC3A2/4F2hc) inhibitory potency (Erastin2 IC₅₀ = 3.5 nM/CCF-STTG1; Erastin IC₅₀ = 200 nM/HT-1080, 140 nM/Calu-1; Glu release assay) and ferropotosis induction efficacy (HT-1080 EC₅₀ = 150 nM/Erastin2 vs. 1.2 μM/Erastin).

基本信息

经验(实验)分子式	C₃₆H₃₅ClN₄O₄
分子量	623.14

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	O=C(N(C1=C(OC(C)C)C=CC(C2=CC=CC=C2)=C1)C(CN3CCN(C(COC4=CC=C(Cl)C=C4)=O)CC3)=N5)C6=C5C=CC=C6

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

Erastin2

2-[[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1′-biphenyl]-3-yl]-4(3H)-quinazolinone