产品说明
一般描述
TIMP1 (tissue inhibitor of metalloproteinase 1) is a glycoprotein and is a member of TIMP family of endogenous MMP (matrix metalloproteinase) inhibitors. Humans contain four TIMPs. All TIMPs contain an N-terminal of 125 residues, a 65-residue C-terminal, and both these domains contain three disulfide bonds. The N-terminal domain inhibits MMPs by folding into a separate unit. TIMP1 is encoded by the gene mapped to human chromosome Xp11.23.
生化/生理作用
TIMP1 functions as a poor inhibitor of MT1 (membrane type 1)-MMP, MT3-MMP, MT5-MMP and MMP-19. It inhibits ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) protein. In human umbilical vein endothelial cells (HUVECs), the down-regulation of TIMP1 and up-regulation of MMP-3 results in aberrant endothelium-dependent vasodilation, EC (endothelial cell) death, and endothelial interruption in a FOXO3 (forkhead box O3)-mediated manner. In patients with CAD (coronary artery disease) and acute coronary syndrome (ACS), the urine levels of this protein are elevated. This protein interacts with Bcl-2 (B cell lymphoma) protein, and induces apoptosis in lung adenocarcinoma cells. The plasma levels of this protein are increased in patients with obesity and obesity-related disorders, such as steatosis, where it participates in pathogenesis of diet-induced hepatic steatosis and glucose intolerance.
外形
In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl?; 1 ?M ZnCl?; 0.05% Brij® L23; 0,05% NaN?
法律信息
Brij is a registered trademark of Croda International PLC
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | human |
| 重组 | expressed in Sf9 cells |
| 测定 | ≥92% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | 28.0 kDa |
| 包装 | pkg of 5 μg |
| manufacturer/tradename | Croda International PLC |
| 杂质 | Endotoxin, tested |
| NCBI登记号 | P01033 |
| 运输 | wet ice |
| 储存温度 | −70℃ |
| Gene Information | human ... TIMP1(7076) |
安全信息
| 象形图 |  |
| 危险声明 | H411 |
| 预防措施声明 | P273 - P391 - P501 |
| 危险分类 | Aquatic Chronic 2 |
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
