产品介绍：
产品说明
应用
Methyl-3,4-dephostatin has been used as:
- an inhibitor for methyltransferases
- a kinase-related inhibitor for human transglutaminase
- a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein
生化/生理作用
Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).
Stable analog of dephostatin; selective protein tyrosine phosphatase 1B and SHPTP-1 inhibitor; does not inhibit CD45-associated phosphatases.
基本信息
| 经验(实验)分子式 | C7H8N2O3 |
| 分子量 | 168.15 |
| MDL编号 | MFCD01076450 |
| PubChem化学物质编号 | 24278575 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | >98% (HPLC) |
| 形式 | powder |
| 颜色 | red-brown |
| 溶解性 | DMSO: soluble 18 mg/mL H2O: insoluble |
| 储存温度 | 2-8℃ |
| SMILES string | CN(N=O)c1ccc(O)c(O)c1 |
| InChI | 1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3 |
| InChI key | XAKAQCMEMMZUEO-UHFFFAOYSA-N |
| Gene Information | human ... PTPN1(5770) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
