产品说明
一般描述
Chemical structure: macrolide
Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.
应用
Erythromycin has been used:
- as a supplement for nutrient broth medium for culturing green fluorescent protein (GFP)- expressing E. coli
- as a model drug to determine small intestinal (SMI) microtissue viability using the MTT assay{254
- as an antibiotic to study the treatment strategies of chronic infections
包装
1, 5 g in poly bottle
生化/生理作用
作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。
抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。
注意
This product is stable in solution at 37℃ for 3 days. Stock solutions should be stored at 2-8℃.
制备说明
This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.
基本信息
| 经验(实验)分子式 | C37H67NO13 |
| 分子量 | 733.93 |
| Beilstein | 75279 |
| EC 号 | 204-040-1 |
| MDL编号 | MFCD00084654 |
| PubChem化学物质编号 | 24894612 |
| NACRES | NA.76 |
产品性质
| 质量水平 | 200 |
| 产品线 | BioReagent |
| 形式 | powder |
| 效能 | ≥850 μg per mg |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | ≤0.1 EU/mg endotoxin |
| 颜色 | white |
| mp | 133 ℃ |
| 溶解性 | 2 M HCl: 50 mg/mL (Stock solutions should be stored at 2-8 ℃. Stable at 37 ℃ for 3 days.) ethanol: soluble (Stock solutions should be stored at 2-8 ℃. Stable at 37 ℃ for 3 days.) |
| 抗生素抗菌谱 | Gram-negative bacteria Gram-positive bacteria |
| 作用机制 | protein synthesis | interferes |
| SMILES string | CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O |
| InChI | 1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1 |
| InChI key | ULGZDMOVFRHVEP-RWJQBGPGSA-N |
| Gene Information | human ... ABCB1(5243), CYP3A4(1576), MLNR(2862) mouse ... Abcb1a(18671), Abcb1b(18669) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
