产品说明
一般描述
Monoclonal Anti-XPO4 (mouse IgG1 isotype) is derived from the hybridoma XP-12 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide. Exportin 4 (XPO4) belongs to the karyopherins protein family. It is conserved amongst higher eukaryotes but, lacks obvious orthologues in yeast.
免疫原
a peptide corresponding to a sequence at the C-terminus of human XPO4.
应用
Monoclonal Anti-XPO4 antibody produced in mouse has been used in immunoblotting and immunofluorescence.
生化/生理作用
Exportin 4 (XPO4) facilitates the nuclear export of eIF-5A (eukaryotic translation initiation factor 5A). In addition, it also mediates transport Sox proteins, as well as regulates Smad signaling. These functions of XPO4 suggests it to be a candidate tumor suppressor gene. Indeed, its involvement in the progression of human hepatocellular carcinomas (HCC) has been demonstrated, implicating this protein as a potential target for treatment of HCC.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | XP-12, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~130 kDa |
| species reactivity | monkey, human, chicken, canine, bovine, hamster |
| 浓度 | ~1.0 mg/mL |
| technique(s) | indirect immunofluorescence: suitable western blot: 1.0-2.0 μg/mL using extracts of HeLa cells |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | Q9C0E2 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... XPO4(64328) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
