产品介绍：
产品说明
一般描述
Trimethyl(trifluoromethyl)silane (TMSCF3) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.
应用
Reactant for:
- Silver-mediated C-H trifluoromethylation of arenes
- Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
- Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
- Palladium-catalyzed oxidative trifluoromethylation of indoles
- Preparation of 5-HT1A antagonists
- Used as difluorocarbene source
TMSCF3 can be used as a reagent for:
- Conversion of aromatic aldehydes to difluoromethylated products.
- C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.
It can also be used in trifluoromethylation of:
- Non-activated aldimines.
- Heterocumulenes.
- Azomethine imines.
包装
10, 50 mL in glass bottle
基本信息
| 线性分子式 | (CH3)3SiCF3 |
| 分子量 | 142.19 |
| Beilstein | 4241868 |
| MDL编号 | MFCD00145454 |
| PubChem化学物质编号 | 57653455 |
| NACRES | NA.22 |
产品性质
| 形式 | liquid |
| 质量水平 | 100 |
| reaction suitability | reaction type: C-C Bond Formation |
| 浓度 | 2 M in THF |
| 折射率 | n |
| 密度 | 0.91 g/mL at 20 ℃ |
| SMILES string | C[Si](C)(C)C(F)(F)F |
| InChI | 1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3 |
| InChI key | MWKJTNBSKNUMFN-UHFFFAOYSA-N |
安全信息
| 象形图 |    |
| 警示用语： | Danger |
| 危险声明 | H225 - H302 - H319 - H335 - H351 |
| 预防措施声明 | P210 - P280 - P301 + P312 + P330 - P305 + P351 + P338 - P370 + P378 - P403 + P235 |
| 危险分类 | Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 补充剂危害 | EUH019 |
| 储存分类代码 | 3 - Flammable liquids |
| WGK | WGK 3 |
| 闪点(F) | 1.4 °F |
| 闪点(C) | -17 ℃ |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
