产品说明
应用
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
包装
1, 5, 10 mg in glass bottle
生化/生理作用
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.
Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC50 7 to 24 nM
外形
A922500 is supplied as a crystalline solid.
制备说明
A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
基本信息
| 经验(实验)分子式 | C26H24N2O4 |
| 分子量 | 428.48 |
| NACRES | NA.77 |
产品性质
| 生物来源 | synthetic (organic) |
| 质量水平 | 100 |
| 测定 | >95% (HPLC) |
| 形式 | powder |
| 分子量 | Mw 428.5 |
| 溶解性 | DMSO: 10 mg/mL, clear, colorless to greenish-yellow |
| 储存温度 | −20℃ |
| InChI key | BOZRFEQDOFSZBV-DHIUTWEWSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
