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MUC1 (EP85) Rabbit Monoclonal Primary Antibody

品牌
Sigma-Aldrich
货号
290R-1
包装型号
规格纯度
价格
1864.22 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Mucin 1 (MUC1) is a transmembrane glycoprotein that protects epithelial cells from injury caused by external stimuli. In addition to this role, MUC1 is involved in cell-cell adhesion, proliferation, motility, invasion and survival. In epithelial cells, MUC1 expression is regulated by binding of TNFα to TNFR1 and activation of the NFαB pathway. In human skin, MUC1 is not expressed in normal epidermis but rather in pre-malignant and malignant conditions. MUC1 has also been expressed in the epidermis of psoriatic plaques of biopsies from patients diagnosed with psoriasis vulgaris. MUC1, in addition to being localized at the apical surface of some suprabasal keratinocytes, is also localized over the entire cell surface of some of these cells and some basal keratinocytes. Conversely, no MUC1 immunoreactivity is typically detected in the epidermis of normal skin. Reactive gastropathy is the second most common diagnosis made on gastric biopsies. Increased epithelial proliferation and modifications of epithelial cytokeratin profile, distinct from those of Helicobacter pylori gastritis, have been previously reported. Loss of MUC1, either patchy or complete, was noted in 67% of the cases. The overexpression of MUC1 was found in 78% of papillary thyroid carcinomas (PTC). Multivariate analysis has shown a strong association of MUC1 expression with the presence of the BRAF (V600E) mutation and lymph node metastasis in PTC. Lymph node metastasis was the most important risk factor of relapse. In a study of thymic epithelial tumors, MUC1 was closely associated with VEGF, p53 and micro-vessel density (MVD). A 94% positive rate of MUC1 expression in thymic carcinomas and 0% in type B3 thymomas, demonstrated a significant difference. The expression of MUC1 was closely related to the grade of malignancy in thymic epithelial tumors. Positive expression of MUC1 was significantly associated with poor outcome in this disease. MUC1 may be useful marker for differentiating thymic carcinoma from type B3 thymoma.5

质量


IVD

IVD

IVD

RUO

联系

MUC1 Positive Control Slides, Product No. 290S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

产品性质

质量水平500
100
生物来源rabbit
偶联物unconjugated
抗体形式culture supernatant
antibody product typeprimary antibodies
克隆EP85, monoclonal
描述For In Vitro Diagnostic Use in Select Regions
形式buffered aqueous solution
species reactivityhuman
包装vial of 0.1 mL concentrate (290R-14)
vial of 0.1 mL concentrate Research Use Only (290R-14-RUO)
vial of 0.5 mL concentrate (290R-15)
vial of 1.0 mL concentrate (290R-16)
vial of 1.0 mL concentrate Research Use Only (290R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (290R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (290R-17)
vial of 7.0 mL pre-dilute ready-to-use (290R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (290R-18-RUO)
manufacturer/tradenameCell Marque
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
同位素/亚型IgG
控制breast, colon (and Associated adenocarcinomas)
运输wet ice
储存温度2-8℃
可视化cytoplasmic

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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