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NKX3.1 (EP356) Rabbit Monoclonal Primary Antibody

品牌
Sigma-Aldrich
货号
441R-1
包装型号
规格纯度
参考价格
1601.64 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

NKX3.1 is a prostate specific androgen-regulated homeobox gene located on chromosome 8.1,2,3 It is difficult to distinguish between high grade prostate adenocarcinoma and high grade infiltrating urothelial carcinoma using hematoxylin and eosin stained specimens.2 Current prostate adenocarcinoma markers such as PSA and PSAP are very useful in determining prostate origin of prostate cancer in other sites, but have lower sensitivity when identifying poorly differentiated compared to well differentiated cases.2 Currently, thrombomodulin and uroplakin are used to identify tumors of urothelial origin; however, their sensitivities are suboptimal.2 In a study by Gurel et al., nearly all cases of metastatic prostate adenocarcinoma were stained by NKX3.1.1 NKX3.1-positive prostate carcinoma cells exhibit nuclear staining.1In another study conducted by Chuang et al., nearly all cases of urothelial carcinoma were negative for NKX3.1.2 Lastly, NKX3.1 has also been found to be expressed in invasive ductal carcinomas (IDC) and invasive lobular carcinomas (ILC) of the breast.3 NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC.3 NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between prostate carcinoma and urothelial carcinomas.1,2

质量


IVD

IVD

IVD

RUO

联系

NKX3.1 Positive Control Slides, Product No. 441S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平500
100
偶联物unconjugated
抗体形式culture supernatant
antibody product typeprimary antibodies
克隆EP356, monoclonal
描述 (For In Vitro Diagnostic Use in Select Regions (See Chart))
形式buffered aqueous solution
species reactivityhuman
包装bottle of 1.0 mL predilute (441R-17)
bottle of 7.0 mL predilute (441R-18)
vial of 0.1 mL concentrate (441R-14)
vial of 0.5 mL concentrate (441R-15)
vial of 1.0 mL concentrate (441R-16)
manufacturer/tradenameCell Marque
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
同位素/亚型IgG
运输wet ice
储存温度2-8℃

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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