NUDT22 (nudix (nucleoside diphosphate linked moiety X)-type motif 22) is a member of the Nudix hydrolase family of pyrophosphatases. Nudix hydrolases contain a characteristic Nudix domain and are responsible for catalyzing the hydrolysis of nucleoside diphosphate derivatives. NUDT22 is a 303 amino acid protein that lacks the nudix box, therefore lacking hydrolase activity. The gene encoding NUDT17 maps to human chromosome 11, which makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome.