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Bruton酪氨酸激酶抑制剂蛋白抗体
产品名称 Anti-IBTK Anti-inhibitor of Bruton tyrosine kinase Antibody 产品介绍
靶标： IBTK 产品别名： BTBD26； BTKI； IBTK； inhibitor of Bruton tyrosine kinase； inhibitor of Bruton tyrosine kinase； inhibitor of Bruton tyrosine kinase； BTK-binding protein； Bruton agammaglobulinemia tyrosine kinase inhibitor； inhibitor of Bruton's tyrosine kinase-alpha； inhibitor of Bruton's tyrosine kinase-beta； inhibitor of Bruton's tyrosine kinase-gamma； Bruton酪氨酸激酶抑制剂蛋白； 背景信息： Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014], |
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