GSG1L is a 331 amino acid multi-pass membrane protein belonging to the GSG1 family. Existing as four alternatively spliced isoforms, GSG1L is encoded by a gene located on human chromosome 16, which encodes over 900 genes, comprises nearly 3% of the human genome and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. A rare disorder known as Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.