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重组ICEBERG蛋白
产品名称 Recombinant CARD18 Recombinant caspase recruitment domain family member 18 protein 产品介绍
基因名： CARD18 产品别名： ICEBERG； UNQ5804； pseudo-ICE； CARD18； caspase recruitment domain family member 18； caspase recruitment domain family member 18； caspase recruitment domain-containing protein 18； ICEBERG caspase-1 inhibitor； caspase-1 inhibitor Iceberg； ICEBERG蛋白； 背景信息： ICEBERG is a member of the death-domain-fold superfamily that is induced by proinflammatory stimuli. Primarily expressed in the heart and placenta, ICEBERG inhibits the generation of IL-1 β which blocks apoptosis during an inflammatory stimulus. ICEBERG inhibits IL-1 beta by associating with caspase-1, thereby preventing caspase-1 from interacting with the pro-apoptotic protein RIP2. The association of ICEBERG with caspase-1 is facilitated by the charge-charge interactions between the prodomain of caspase-1 and the surface charge of ICEBERG. The association of caspase-1 with RIP2 will inhibit apoptosis by generating IL-1 beta. However, the association of caspase-1, which serves both pro and antiapoptotic roles, with ICEBERG induces apoptosis by inhibiting the generation of IL-1 β. |
广州伟伯科技有限公司
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