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重组RAGEF2蛋白
产品名称 Recombinant RAPGEF6 Recombinant Rap guanine nucleotide exchange factor 6 protein 产品介绍
基因名： RAPGEF6 产品别名： KIA001LB； PDZ-GEF2； PDZGEF2； RA-GEF-2； RAGEF2； RAPGEF6； Rap guanine nucleotide exchange factor 6； Rap guanine nucleotide exchange factor 6； rap guanine nucleotide exchange factor 6； PDZ domain containing guanine nucleotide exchange factor (GEF) 2； PDZ domain-containing guanine nucleotide exchange factor 2； PDZ domain-containing guanine nucleotide exchange factor I； Rap guanine nucleotide exchange factor (GEF) 6； RAGEF2蛋白； 背景信息： RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B. |
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