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重组Sp140核体蛋白(SP140)
产品名称 重组核自身抗原SP140蛋白 Recombinant SP140 产品介绍
基因名： SP140 产品别名： LYSP100； LYSP100-A； LYSP100-B； SP140； SP140 nuclear body protein； SP140 nuclear body protein； nuclear body protein SP140； lymphoid-restricted homolog of Sp100； lymphoid-specific SP100 homolog； nuclear autoantigen Sp-140； speckled 140 kDa； Sp140核体蛋白(SP140)； 核自身抗原SP140； 背景信息： SP140 is an 867 amino acid cytoplasmic and nuclear protein that is highly expressed in spleen and peripheral blood leukocytes. SP140 is a component of the nuclear body that may be involved in trafficking between the nucleus and the cytoplasm. SP140 is induced by interferons and contains a bromo domain, a HSR domain, a PHD-type zinc finger and a SAND domain. It is thought that SP140 may participate in the pathogenesis of acute promyelocytic leukemia and viral infection. SP140 is expressed as three isoforms produced by alternative splicing and are designated isoform LYSp100-A, isoform LYSp100-B and isoform SP140. |
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