LRTM2 (Leucine-Rich Repeats And Transmembrane Domains 2) is located on human chromosome 12p13.33. The LRTM2 protein is restrictedly expressed toward brain. Structurally, the encoded LRTM2 protein is reported to be 41158 Da in mass. The LRTM2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 224 organisms have orthologs with human gene LRTM2. LRTM2 is associated with some diseases, such as Preretinal Fibrosis. An important paralog of this gene is LRFN2.