The phosphatidylinositol-4-phosphate adaptor protein-2 (FAPP2, also known as PLEKHA8) gene encodes a cytoplasmic lipid transferase with a plekstrin homology domain that has been implicated in vesicle maturation and transport from trans-Golgi to the plasma membrane. FAPP2 plays a key role in glycosphingolipid (GSL) production using its C-terminal domain to transport newly synthesized glucosylceramide away from the cytosol-facing glucosylceramide synthase in the cis-Golgi for further anabolic processing. FAPP2, a PI4P effector and glycosphingolipid-binding protein, is recruited to the hepatitis C virus (HCV) replication complex and is required for HCV genome replication and replication complex formation.