Syntaxin 19, also known as STX19, is a 294 amino acid peripheral membrane protein that contains one t-SNARE coiled-coil homology domain and belongs to the syntaxin family, suggesting a role in synaptic vesicle fusion. The gene encoding Syntaxin 19 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.