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RNA结合蛋白25抗体
产品名称 Anti-RBM25 Anti-RNA binding motif protein 25 Antibody 产品介绍
靶标： RBM25 产品别名： NET52； RED120； RNPC7； S164； Snu71； fSAP94； RBM25； RNA binding motif protein 25； RNA binding motif protein 25； RNA-binding protein 25； Arg/Glu/Asp-rich protein, 120 kDa； RNA-binding region (RNP1, RRM) containing 7； RNA-binding region-containing protein 7； U1 small nuclear ribonucleoprotein 1SNRP homolog； arg/Glu/Asp-rich protein of 120 kDa； functional spliceosome-associated protein 94； RNA结合蛋白25； 背景信息： RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. |
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