c3orf75 (TMEM103, ATP1, Q9NXJ3, AK000218, FLJ20211 and most recently, ELP6) is a conserved open reading frame within human chromosome 3. c3ORF75 was recently reported to encode ELP6, a subunit of the Elongator complex, and to have a function in cell migration and tumorigenicity. Conserved from yeast to humans, Elongator is a protein complex implicated in multiple processes including transcription regulation, α-tubulin acetylation, and tRNA modification, and its defects have been shown to cause human diseases such as familial dysautonomia. Elongator consists of two copies of six core subunits (Elp1, Elp2, Elp3, Elp4, Elp5, and Elp6) that are organized into two subcomplexes: Elp1/2/3 and Elp4/5/6 and form a stable assembly of 850 kDa in size.