The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The primary function of these motifs is to provide a versatile structural framework to mediate the formation of protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. LRRC10 (leucine-rich repeat-containing protein 10), also known as HRLRRP or LRRC10A, is a 277 amino acid protein that contains eight LRR repeats. Localized to the nucleus, LRRC10 may play an important role in cardiac development and/or cardiac function. The gene that encodes LRRC10 maps to human chromosome 12q15 and murine chromosome 10 D2.