Neurensin-2 is a 204 amino acid multi-pass membrane protein belonging to the VMP family that may be involved in the transport and maintenance of vesicles. Expressed in brain, Neurensin-2 localizes to cell bodies of hippocampus, diagonal band, amygdaloid nucleus, and habenula nucleus, and is a potential tumor suppressor gene and candidate biomarker for long-term survival in patients with hepatocellular carcinoma (HCC). The gene encoding Neurensin-2 maps to human chromosome 20, which comprises approximately 2% of the human genome, contains nearly 63 million bases and encodes over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.