The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. The Zinc finger and BTB domain-containing protein 11 (ZBTB11) contains 1 BTB (POZ) domain and 12 C2H2-type zinc fingers suggesting a role in transcription regulation. The gene encoding ZBTB11 maps to chromosome 3, which contains over 1,100 genes. Notably, a chemokine receptor gene cluster and a variety of human cancer related loci reside on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells as well.