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重组糖皮质激素调节元件结合蛋白2
产品名称 Recombinant GMEB2 Recombinant glucocorticoid modulatory element binding protein 2 protein 产品介绍
基因名： GMEB2 产品别名： GMEB-2； P79PIF； PIF79； GMEB2； glucocorticoid modulatory element binding protein 2； glucocorticoid modulatory element binding protein 2； glucocorticoid modulatory element-binding protein 2； DNA-binding protein p79PIF； PIF p79； parvovirus initiation factor, p79； 糖皮质激素调节元件结合蛋白2； 背景信息： GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication. |
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