RRP12 is a 1,297 amino acid single-pass membrane protein that participates in ribosomal assembly. Expressed in testis and ovary, RRP12 belongs to the RRP12 family and localizes to the nucleus. RRP12 may be involved in coupling the control of ribosome production to the regulation of other cellular processes during cell cycle progression. In conjunction with Dim2, RRP12 is thought to be involved in the nucleocytoplasmic translocation of pre-ribosomes during ribosome assembly. RRP12 exists two alternatively spliced isoforms and is encoded by a gene located on human chromosome 10q24.1.