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重组ATP酶2C2蛋白
产品名称 重组钙离子转运ATP酶C2(ATP2C2)蛋白 Recombinant ATP2C2 产品介绍
基因名： ATP2C2 产品别名： SPCA2； ATP2C2； ATPase secretory pathway Ca2+ transporting 2； ATPase secretory pathway Ca2+ transporting 2； calcium-transporting ATPase type 2C member 2； ATPase 2C2； ATPase, Ca++ transporting, type 2C, member 2； Ca(2+)/Mn(2+)-ATPase 2C2； secretory pathway Ca(2+)-ATPase 2； secretory pathway Ca(2+)-transporting ATPase type 2； secretory pathway calcium ATPase 2； ATP酶2C2； 钙离子转运ATP酶C2(ATP2C2)； 背景信息： The family of P-type Ca2+-transport ATPases is made up of three subfamilies: sarco(endo)plasmic-reticulum Ca2+ ATPases (SERCA), plasma- membrane Ca2+ ATPases (PMCA), and secretory-pathway Ca2+ ATPases (SPCA). The SPCA1 protein (encoded for by the ATP2C1 gene) is a Ca2+/ Mn2+-transport ATPase. It localizes to the Golgi apparatus and, together with SERCA2, it is responsible for the ionic milieu in the Golgi lumen. SPCA2 (encoded by the ATP2C2 gene) also localizes to the golgi apparatus and has a higher enzymatic turnover rate than that of SPCA1 while having a high affinity for cytosolic Ca2+. The enzymatic properties of the human SPCA2 enzyme and the restriction of its tissue expression to the gastrointestinal and respiratory tracts, prostate, thyroid, salivary, and mammary glands may, in principle ,define a Ca2+-ATPase pump with a specific physiological role in secretory cells. |
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