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重组G蛋白偶联受体109B(GPR109B)
产品名称 重组G蛋白偶联受体HM74 Recombinant HCAR3 产品介绍
基因名： HCAR3 产品别名： GPR109B； HCA3； HM74； PUMAG； Puma-g； HCAR3； hydroxycarboxylic acid receptor 3； hydroxycarboxylic acid receptor 3； hydroxycarboxylic acid receptor 3； G-protein coupled receptor 109B； G-protein coupled receptor HM74； G-protein coupled receptor HM74B； GTP-binding protein； hydroxy-carboxylic acid receptor 3； niacin receptor 2； nicotinic acid receptor 2； putative chemokine receptor； G蛋白偶联受体109B(GPR109B)； G蛋白偶联受体HM74蛋白； 背景信息： HM74 is a member of the G protein coupled receptor (GPCR) superfamily. In humans, HM74 is encoded by two different genes (GPR109A and GPR109B) that express two distinct proteins, namely HM74A and HM74B (also known as simply HM74), which are 96% homologous. In mice and rats, only one gene (deisngnated Gpr109a) encodes the HM74 protein. HM74B is a G(i) protein-coupled receptor that mediates the metabolic effects of nicotinic acid. Localizing to the cell membrane, HM74B is highly expressed in adipocytes, immune cells and spleen and, like all members of the GPCR superfamily, contains seven transmembrane domains. HM74B lacks the characteristic N-linked glycosylation sites that are present in other GPCR family members and also shows a more diverged amino acid sequence homology from most family members, implying different ligand specificity |
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